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How we can convert liver cell in to nerve cell overview in 2018

YES, YOU KNOW ABOUT LEAPFROGGING ?
Recent scientists developed  a method by which transmuting exsisting cells, into a totally new form . 
This important discovery could help in generating essential cell in an ailing patient or cancerous agents into benign cells.

RESEARCHERS - Stanford university  of medicine, In the laboratory  they have been directaly transformed fully matured mice liver cell into a nerve cell, this process was accomplished  by introduction of just three genes didn't required cells to first inter a pluripotent state 

PROCESS- GENE EXPRESSION FALLOWED WITH TRANSDIFFERENTIATION TECHNIQUES. 
 Hepatocytes arise from one of three classes of embryonic tissue called the endodermal; neurons from the ectoderms, accomplish  the transformation of hepatocytes, researchers  used a virus to introduce the three genes: Brn2, Ascl1, Myt1l.

The hepatocytes  began to exhibit neuronal
Characteristics  with in 2 weeks, and express the neuronal gene with in 3 weeks.
Simultaneously, cell began suppress the expression of lever-specific genes.
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